Ireland’s Tim Murtagh placed himself on the Lord’s Honours Board as he took 5/13 to help rattle England out for 85 in the lone Test between the two.
Debutant Mark Adair and Boyd Rankin took 3/32 and 2/5 respectively as England struggled with the bat just days after winning the World Cup at the same venue.
Joe Denly, Sam Curran and Ollie Stone were the only batsmen to get double figures.
In reply, Ireland got 55 from Andy Balbirnie and 36 from Paul Stirling on their way to 207 all out.
England faced just one over before the end the day and nightwatchman Jack Leach successful navigated 6 tricky deliveries as England went to stumps at 0/0 and behind by 122 runs.